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Los Angeles Chargers vs. Arizona Cardinals Preview

Spread, Betting Line and Week 12 Odds
Los Angeles Chargers vs. Arizona Cardinals Preview

NFL Predictions breaks down each NFL matchup of the season, sharing betting information and statistics that helps you get into the game.

The Arizona Cardinals (4-7) host the Los Angeles Chargers (5-5) at State Farm Stadium on Sunday, November 27, 2022. The Chargers last hit the field against the Kansas City Chiefs, and they lost 30-27. In their most recent outing, the Cardinals took on the 49ers and fell short by a final score of 38-10.

The Chargers are field goal favorites in their matchup against the Cardinals.

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Odds and Game Info

  • Game Day: Sunday, November 27, 2022
  • Game Time: 4:05 PM ET
  • TV Channel: CBS
  • Location: Glendale, Arizona
  • Stadium: State Farm Stadium
  • Spread Favorite: Chargers (-3)
  • Moneyline: Chargers (-150), Cardinals (+125)

Chargers Betting Info

  • The Chargers have posted a 5-4-1 record against the spread this season.
  • In games they have played as at least 3-point favorites this season, the Chargers are 2-3-1 against the spread.
  • The Chargers have not hit the over on a point total in 10 games with a set over/under.
  • The Chargers have won 71.4% of the time they have played as moneyline favorites (5-2).
  • The Chargers have gone 4-2 when playing as a moneyline favorite with odds of -150 or shorter (66.7%).

Cardinals Betting Info

  • Arizona is 5-6-0 against the spread this season.
  • In games this year in which they were an underdog by 3 points or more, the Cardinals have a 3-4 record against the spread.
  • Arizona has hit the over in one of 11 games with a set total (9.1%).
  • This season, the Cardinals have been the underdog eight times and won three of those games.
  • The Cardinals have a record of 1-5 in games where oddsmakers have them as underdogs of at least +125 on the moneyline.

Check out our NFL sportsbook for live odds.

Chargers vs. Cardinals Comparison

Compare 2022 season stats for Chargers and Cardinals
Chargers Stats Cardinals
263.8 Pass yards 223
220.6 Pass yards against 245.4
87.9 Rush yards 108.9
148.4 Rush yards against 114.9
+1 Turnover differential +3

Chargers Leaders

  • Justin Herbert has recorded 2,730 yards (273 ypg) on 277-of-416 passing with 16 touchdowns compared to seven interceptions this season.
  • Austin Ekeler has carried the ball 123 times for a team-high 534 yards (53.4 per game) with seven scores. He has also caught 69 passes for 437 yards and four receiving touchdowns.
  • This season, Sony Michel has carried the ball 36 times for 106 yards (10.6 per game).
  • Mike Williams' leads his squad with 510 yards as a receiver. He's racked up that yardage on 38 catches (out of 60 targets) and scored three touchdowns.
  • Josh Palmer has hauled in 45 receptions totaling 496 yards, finding the end zone three times as a receiver so far this campaign.
  • Khalil Mack has racked up seven sacks to lead the team, while also picking up nine TFL and 32 tackles.
  • Los Angeles' leading tackler, Derwin James, has 92 tackles, five TFL, and four sacks this year.
  • Bryce Callahan leads the team with two interceptions, while also putting up 29 tackles, two TFL, and five passes defended.

Cardinals Leaders

  • Kyler Murray has been a dual threat for Arizona this season. He has 2,168 passing yards (240.9 per game) while completing 66.7% of his passes. He's thrown 12 touchdown passes and six interceptions this season. On the ground, he's compiled 359 yards (39.9 ypg) on 59 carries with two rushing touchdowns.
  • James Conner has compiled 356 yards on 96 carries with four touchdowns, while also catching 24 passes for 151 yards.
  • DeAndre Hopkins' 487 receiving yards (97.4 yards per game) are best on his team. He has 45 catches on 58 targets with two touchdowns.
  • Marquise Brown has put up a 485-yard season so far with three touchdowns. He's caught 43 passes on 64 targets.
  • Rondale Moore's 56 targets have resulted in 41 catches for 414 yards and one touchdown.
  • J.J. Watt has collected 5.5 sacks to pace the team, while also recording seven TFL and 19 tackles.
  • Budda Baker is the team's tackle leader this year. He's picked up 85 tackles, one TFL, and one interception.
  • Zaven Collins has a team-leading one interception to go along with 71 tackles, six TFL, two sacks, and four passes defended.

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Terms Apply. 21+ only. Bet with your head, not over it. Gambling problem? Call 1-800-GAMBLER (NJ), 1-800-522-4700 (CO), 1-800-BETS-OFF (IA), 800-994-8448 (IN), 1-800-589-9966 (OH).